What does coagulation refer to in the context of hematology?

Coagulation in the context of hematology refers to the process of blood clot formation. When a blood vessel is injured, the body initiates a series of complex biochemical processes that result in the transformation of liquid blood into a semi-solid gel to prevent excessive bleeding. This involves the activation of platelets and the coagulation cascade, culminating in the generation of fibrin, which helps to stabilize the clot.

Understanding coagulation is crucial for various medical conditions, such as hemophilia or thrombosis, where there may be abnormalities in the clotting process. Recognizing the significance of coagulation helps healthcare professionals assess the body's ability to control bleeding and can guide treatment options accordingly. This concept is foundational in hematology, as it directly relates to the management of patients with bleeding disorders or those requiring surgical interventions.